Iowa State vs. Illinois odds, score prediction: 2024 NCAA Tournament picks, Sweet 16 best bets by proven model

The second-seeded Iowa State Cyclones attempt to slow down Illinois’ offense when they face the No. 3 seed Fighting Illini in the East Region semifinals of the 2024 NCAA Tournament on Thursday. Iowa State (29-7) has reached the Sweet 16 for the second time in three years after posting victories against South Dakota State and Washington State. The Cyclones now take on high-scoring Illinois (28-8), which defeated Morehead State 85-69 and Duquesne 89-63 en route to their first Sweet 16 appearance since 2005.

Tipoff from TD Garden in Boston is set for 10:09 p.m. ET. The Cyclones are 1.5-point favorites in the latest Iowa State vs. Illinois odds via SportsLine consensus, while the over/under for total points scored is 146. Before entering any Illinois vs. Iowa State picks, make sure you see the college basketball predictions and betting advice from the SportsLine Projection Model. 

The model simulates every Division I college basketball game 10,000 times. It enters the Sweet 16 round of the 2024 NCAA tournament on a 152-109 roll on all top-rated college basketball picks dating back to last season, returning more than $1,800 for $100 players. It also has a strong 32-21 (+890) record on top-rated spread picks this season, and it called 13 Sweet 16 teams this year. Anyone following has seen huge returns.

Now, the model has set its sights on Illinois vs. Iowa State and revealed its March Madness picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several college basketball odds and trends for Iowa State vs. Illinois:

Iowa State vs. Illinois spread: Iowa State -1.5Iowa State vs. Illinois over/under: 146 pointsIowa State vs. Illinois money line: Iowa State -125, Illinois +105ISU: 26-10 ATS this season ILL: 21-13-1 ATS this season Iowa State vs. Illinois picks: See picks at SportsLine

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