Heavyweights clash when the ninth-ranked Kentucky Wildcats take on the No. 12 Louisville Cardinals in the 2025 Battle of the Bluegrass on Tuesday night. Kentucky is coming off a 107-59 win over Valparaiso on Friday, while Louisville downed Jackson State 106-70 on Thursday. The Wildcats (2-0), who tied for sixth in the SEC a year ago at 10-8 and were 24-12 overall, are 4-6 on the road since the start of last season. The Cardinals (2-0), who tied for second in the ACC at 18-2 and were 27-8 overall in 2024-25, are 16-3 on their home court since last November.
Tipoff from KFC Yum! Center in Louisville, Ky., is set for 8 p.m. ET. After opening at -4.5, Louisville is now a 6.5-point favorite in the latest Kentucky vs. Louisville odds from SportsLine consensus, while the over/under for total points scored is 173.5. Before making any Louisville vs. Kentucky picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.
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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.
Now, the model has simulated Kentucky vs. Louisville 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Louisville vs. Kentucky:
Kentucky vs. Louisville spread:
Louisville -6.5
Kentucky vs. Louisville over/under:
173.5 points
Kentucky vs. Louisville …
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