The 2025-26 college basketball schedule continues on Wednesday, Nov. 12, with over 50 games involving Division I teams. Two contests feature ranked teams in action with No. 1 Houston vs. Oakland (+28.5) and No. 12 Tennessee vs. North Florida (+40.5). The Cougars will play their first game as the top-ranked team after leapfrogging Purdue in the AP Poll, while the Volunteers, who are amongst the biggest favorites per the college basketball odds, will take on the Ospreys for the first time ever.
Other college basketball lines of note include Minnesota vs. Missouri (-6.5), Marquette vs. Little Rock (+20.5) and Oregon vs. South Dakota State (+16.5). With just two games under most teams’ belts and little data to go off, what are the Wednesday college basketball best bets to pursue for a CBB parlay? Before locking in any college basketball picks, you’ll want to see the college basketball predictions and betting advice from SportsLine’s proven computer model.
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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.
Now, the model has scoured the latest college basketball odds and locked in three confident college basketball picks. If you successfully parlay its college basketball betting picks, you’d be looking at a payout of nearly +1100. You can only see the model’s college basketball picks at SportsLine.
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Top college basketball picks for Wednesday, Nov. 12
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