Tennessee vs. Mississippi State prediction, odds: 2025 college basketball picks, Jan. 21 bets by proven model

The No. 6 Tennessee Volunteers will host the No. 14 Mississippi State Bulldogs on Tuesday night in SEC play and the conference continues to look like the deepest in the land. After winning their first 14 games, the Volunteers have lost two of four and are now 16-2 overall and 3-2 in the SEC. Meanwhile, the Bulldogs are 15-3 on the season and are also 3-2 in the league, and they should be emboldened after winning by 17 points in Knoxville as 9.5-point underdogs last year.

Tipoff from Thompson-Boling Arena Knoxville, Tenn., is set for 7 p.m. ET. The Volunteers are a 7-point favorite in the latest Tennessee vs. Mississippi State odds from SportsLine consensus, while the over/under for total points scored is 140.5. Before entering any Mississippi State vs. Tennessee picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 11 of the 2024-25 season on a 195-134 betting roll (+2882) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Tennessee vs. Mississippi State. You can head to SportsLine to see its picks. Here are several college basketball betting lines and trends for Mississippi State vs. Tennessee:

Tennessee vs. Mississippi State spread: Tennessee -7
Tennessee vs. Mississippi State over/under: 140.5 points Tennessee vs. Mississippi State money line: Tennessee -298, MSU +236Tennessee vs. Mississippi State picks: See picks at SportsLine
Tennessee vs. Mississippi State streaming: FuboTV (Try for free)

Why you should back Tennessee

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