Knicks vs. Celtics odds, prediction, spread, start time: 2025 NBA playoff picks, Game 6 bets by proven model

The second-seeded Boston Celtics will look to even their best-of-seven 2025 NBA Eastern Conference semifinal series with the third-seeded New York Knicks when they meet in Game 6 on Friday night. Boston avoided elimination with a 127-102 win in Game 5 as both of the Celtics’ win in this 2025 NBA playoffs series have come by at least 22 points. The Celtics (61-21) are looking to reach the conference finals for the fourth straight year, while the Knicks (51-31) have lost in the Eastern Conference semifinals in each of the past two seasons. Precious Achiuwa (ankle) is listed as questionable for the Knicks.

Tipoff is at 8 p.m. ET from Madison Square Garden in New York City, where the home team went 27-14 in the regular season. New York has won seven of the last 11 postseason meetings with Boston. The Knicks are 2.5-point favorites in the latest Celtics vs. Knicks odds from DraftKings Sportsbook, while the over/under for total points scored is 211.5, an increase from opening at 209.5. The Knicks are -144 on the money line (risk $144 to win $100), while the Celtics are +122 (risk $100 to win $122). Before making any Knicks vs. Celtics picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the second week of the conference semifinals of the 2025 NBA playoffs on a sizzling 159-117 roll on all top-rated NBA picks, returning nearly $4,000. It is also 23-11 (68%) on top-rated NBA against-the-spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Celtics vs. Knicks 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Knicks vs. Celtics:

Celtics vs. Knicks spread: New York -2.5 at…..

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